The Effect of Exercise on the Excretion of Uric Acid with a Note on the Influence of Benzoic Acid on Uric Acid Elimination in Liver Diseases by Armand

No satisfactory explanation has been offered for the uricacidemia which is apt to occur in such clinical conditions as eclampsia, chloroform poisoning, cardiac failure, and pneumonia, but interestingly in these same conditions an elevation of the lactic acid of the blood is not uncommon (1). In view of the fact that ingested lactic acid causes a temporary decrease in the excretion of uric acid as Gibson and Doisy (2), and the writer (3) have observed, the possibility exists that accumulation of lactic acid in the body may be one of the causes for uric acid retention. As a means of testing whether excessive production of lactic acid can influence the excretion of uric acid, the effect of strenuous exercise was studied.